EEMCS
Home > Publications
Home University of Twente
Education
Research
Prospective Students
Jobs
Publications
Intranet (internal)
 
 Nederlands
 Contact
 Sitemap
 Search
 Organisation

EEMCS EPrints Service


8848 Fast,ultrasensitive virus detection using a Young interferometer sensor
 Home Policy Brochure Browse Search User Area Contact Help

Ymeti, A. and Greve, J. and Lambeck, P.V. and Wink, T. and van Hovell, S.W.F.M. and Beumer, T.A.M. and Wijn, R.R. and Heideman, R.G. and Subramaniam, V. and Kanger, J.S. (2007) Fast,ultrasensitive virus detection using a Young interferometer sensor. Nano letters, 7 (2). pp. 394-397. ISSN 1530-6984 *** ISI Impact 12,186 ***

Full text available as:

PDF
 - Univ. of Twente only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
159 Kb

Official URL: http://dx.doi.org/10.1021/nl062595n

Exported to Metis

Abstract

We report the application of an integrated optical Young interferometer sensor for ultrasensitive, real-time, direct detection of viruses. We have validated the sensor by detecting herpes simplex virus type 1 (HSV-1), but the principle is generally applicable. Detection of HSV-1 virus
particles was performed by applying the virus sample onto a sensor surface coated with a specific antibody against HSV-1. The performance of the sensor was tested by monitoring virus samples at clinically relevant concentrations. We show that the Young interferometer sensor can specifically and sensitively detect HSV-1 at very low concentrations (850 particles/mL). We have further demonstrated that the sensor can specifically detect HSV-1 suspended in serum. Extrapolation of the results indicates that the sensitivity of the sensor approaches the detection of a single virus particle binding, yielding a sensor of unprecedented sensitivity with wide applications for viral diagnostics.

Item Type:Article
Research Group:TNW-NBP: Nanobiophysics, EWI-IOMS: Integrated Optical MicroSystems
Research Program:MESA-General
Research Project:Ontwikkeling van een meerkanaals geïntegreerde interferometer immuunsensor
Additional Information:Web release date is December 29th, 2006.
ID Code:8848
Status:Published
Deposited On:14 July 2008
Refereed:Yes
International:Yes
ISI Impact Factor:12,186
More Information:statisticsmetis

Export this item as:

To request a copy of the PDF please email us request copy

To correct this item please ask your editor

Repository Staff Only: edit this item